Kazuo Sakashita Selected Research

Juvenile Myelomonocytic Leukemia

2/2022	A retrospective analysis of azacitidine treatment for juvenile myelomonocytic leukemia.
1/2019	Successful hematopoietic stem cell transplantation from an HLA-mismatched parent for engraftment failure after unrelated cord blood transplantation in patients with juvenile myelomonocytic leukemia: Report of two cases.
11/2018	Panobinostat inhibits the proliferation of CD34+ CD38- cells under stimulation of hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia.
8/2016	Diagnosis and treatment of juvenile myelomonocytic leukemia.
3/2016	Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34(+) cells of juvenile myelomonocytic leukemia.
2/2016	[Juvenile myelomonocytic leukemia (JMML): recent advances in molecular pathogenesis and treatment].
2/2015	Transplantation for juvenile myelomonocytic leukemia: a retrospective study of 30 children treated with a regimen of busulfan, fludarabine, and melphalan.
3/2011	Disappearance of minimal residual disease after the early withdrawal of immunosuppressants in a patient with juvenile myelomonocytic leukemia.
7/2010	Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations.
11/2007	Acquisition of loss of the wild-type NRAS locus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation.

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Kazuo Sakashita Research Topics

Disease

10	Juvenile Myelomonocytic Leukemia 02/2022 - 11/2007
10	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/2021 - 07/2010
10	Neoplasms (Cancer) 02/2020 - 02/2009
8	Hematologic Neoplasms (Hematological Malignancy) 02/2020 - 09/2009
7	Immunoglobulin Light-chain Amyloidosis 01/2008 - 01/2003
6	Leukemia 03/2020 - 02/2007
6	Disease Progression 01/2020 - 01/2011
4	Hypersensitivity (Allergy) 01/2022 - 02/2016
4	Residual Neoplasm 02/2012 - 02/2010
3	Neuroblastoma 01/2022 - 09/2018
3	Amyloidosis 05/2005 - 01/2003
2	Thrombocytopenia (Thrombopenia) 05/2022 - 01/2022
2	Asthma (Bronchial Asthma) 01/2022 - 04/2003
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 09/2020 - 11/2014
2	Graft vs Host Disease (Graft-Versus-Host Disease) 05/2020 - 03/2015
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2020 - 05/2007
2	Febrile Neutropenia 02/2020 - 02/2009
2	Chromosome Aberrations (Chromosome Abnormalities) 01/2020 - 10/2004
2	Cytomegalovirus Infections (Inclusion Disease) 10/2019 - 12/2004
2	Hemorrhagic Cystitis 06/2018 - 08/2009
2	Necrosis 01/2018 - 02/2016
2	Ependymoma 01/2018 - 01/2016
2	Myeloproliferative Disorders (Myeloproliferative Disorder) 08/2016 - 02/2016
2	Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell) 07/2016 - 02/2015
2	Chronic Granulomatous Disease 01/2015 - 03/2014
2	Multiple Organ Failure (MODS) 04/2012 - 07/2010
2	Polyneuropathies (Polyneuropathy) 04/2012 - 01/2010
2	Sepsis (Septicemia) 04/2012 - 07/2010
2	Infections 07/2010 - 02/2009
2	Autosomal Recessive 3 Severe Congenital Neutropenia 05/2009 - 10/2004
1	Atopic Dermatitis (Atopic Eczema) 01/2022
1	Seasonal Allergic Rhinitis (Hay Fever) 01/2022
1	Allergic Rhinitis 01/2022
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2021
1	Hemophilia B (Haemophilia B) 01/2021
1	Intellectual Disability (Idiocy) 09/2020
1	Immune System Diseases (Immune Disorders) 05/2020
1	Neutropenia 02/2020
1	Brain Neoplasms (Brain Tumor) 02/2020
1	Fever (Fevers) 02/2020
1	Philadelphia Chromosome 01/2020
1	Tumor Lysis Syndrome 01/2020
1	Acute Kidney Injury (Acute Renal Failure) 01/2020
1	Brain Diseases (Brain Disorder) 12/2019
1	Heart Failure 12/2019
1	Anaphylaxis (Anaphylactic Shock) 11/2019
1	Primary Ovarian Insufficiency 01/2019
1	Infertility (Sterility) 01/2019

Drug/Important Bio-Agent (IBA)

7	Melphalan (Alkeran)FDA LinkGeneric 02/2015 - 01/2003
4	Dexamethasone (Maxidex)FDA LinkGeneric 01/2020 - 01/2003
4	Vincristine (Oncovin)FDA LinkGeneric 07/2016 - 01/2003
4	Proteins (Proteins, Gene)FDA Link 01/2016 - 01/2003
3	Anti-Bacterial Agents (Antibiotics)IBA 02/2020 - 02/2009
3	Intravenous Immunoglobulins (IVIG)FDA Link 01/2016 - 08/2003
3	fludarabineIBA 02/2015 - 09/2009
3	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2005 - 01/2003
2	Azacitidine (5 Azacytidine)FDA Link 02/2022 - 11/2018
2	Methotrexate (Mexate)FDA LinkGeneric 05/2020 - 01/2020
2	Histones (Histone)IBA 03/2020 - 05/2007
2	Piperacillin FDA LinkGeneric 02/2020 - 02/2009
2	C-Reactive ProteinIBA 02/2020 - 08/2015
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2018 - 05/2009
2	Ganciclovir (Cytovene)FDA LinkGeneric 06/2018 - 08/2009
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 08/2016 - 02/2016
2	HLA Antigens (Human Leukocyte Antigens)IBA 04/2016 - 01/2016
2	DNA (Deoxyribonucleic Acid)IBA 01/2016 - 02/2012
2	Valproic Acid (Depakote)FDA LinkGeneric 01/2016 - 01/2015
2	Interleukin-8 (Interleukin 8)IBA 08/2015 - 09/2006
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 11/2014 - 09/2009
2	CytokinesIBA 07/2010 - 09/2006
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 09/2006 - 10/2004
2	Immunoglobulins (Immunoglobulin)IBA 05/2005 - 06/2004
1	Indicators and Reagents (Reagents)IBA 05/2022
1	AllergensIBA 01/2022
1	Immunoglobulin E (IgE)IBA 01/2022
1	blinatumomabIBA 11/2021
1	Inotuzumab OzogamicinIBA 11/2021
1	Factor VIIa (Activated Factor VII)IBA 01/2021
1	recombinant FVIIa (rFVIIa)FDA Link 01/2021
1	Factor X (Stuart Factor)IBA 01/2021
1	Factor IX (Coagulation Factor IX)FDA LinkGeneric 01/2021
1	Tacrolimus (Prograf)FDA LinkGeneric 05/2020
1	Methylprednisolone FDA LinkGeneric 05/2020
1	Messenger RNA (mRNA)IBA 03/2020
1	Dasatinib (BMS 354825)FDA Link 01/2020
1	Ifosfamide FDA LinkGeneric 12/2019
1	Follicle Stimulating Hormone (Follitropin)FDA Link 01/2019
1	thymoglobulin FDA Link 01/2019

Therapy/Procedure

18	Drug Therapy (Chemotherapy) 01/2022 - 01/2003
18	Hematopoietic Stem Cell Transplantation 11/2021 - 09/2009
14	Therapeutics 11/2021 - 08/2003
13	Transplantation 09/2020 - 10/2004
4	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 10/2017 - 01/2003
4	Stem Cell Transplantation 01/2016 - 06/2004
3	Blood Transfusion (Blood Transfusions) 01/2022 - 10/2017
2	Platelet Transfusion (Blood Platelet Transfusions) 01/2022 - 02/2007
2	Bone Marrow Transplantation (Transplantation, Bone Marrow) 04/2016 - 08/2009
1	Erythrocyte Transfusion 01/2022
1	Cell Transplantation 01/2020
1	Combination Drug Therapy (Combination Chemotherapy) 01/2020